Al Capone-style bootlegging, hijacking, gang-banging, shooting and corrupting have Americans, their neighborhoods, their children and their lives by the throats, and nothing short of another Wickersham Commission can save them. The Wickersham Commission was created amid the violence of Prohibition, and it astutely recommended an end to Prohibition to stop the violence.
Judge James Gray organized a top ten list of drug policy goals and published it in the Daily Pilot.
Also, I have an article titled "The Failure of Drug Prohibition - A Law Enforcement Perspective." It was published in the June / July 2009 edition of Blue Line, which is Canada's national law enforcement magazine. (Note that the graph looked OK in print but it's blurry in the online version.)